| Top 50 Runs (2001) | |||
| RK | PLAYER | YRS | R |
| 1 | Rickey Henderson | 23 | 2248 |
| 2 | Ty Cobb | 24 | 2246 |
| 3 | Hank Aaron | 23 | 2174 |
| 4 | Babe Ruth | 22 | 2174 |
| 5 | Pete Rose | 24 | 2165 |
| 6 | Willie Mays | 22 | 2062 |
| 7 | Cap Anson | 27 | 1996 |
| 8 | Stan Musial | 22 | 1949 |
| 9 | Lou Gehrig | 17 | 1888 |
| 10 | Tris Speaker | 22 | 1882 |
| 11 | Mel Ott | 22 | 1859 |
| 12 | Frank Robinson | 21 | 1829 |
| 13 | Eddie Collins | 25 | 1821 |
| 14 | Carl Yastrzemski | 23 | 1816 |
| 15 | Ted Williams | 19 | 1798 |
| 16 | Paul Molitor | 21 | 1782 |
| 17 | Charlie Gehringer | 19 | 1774 |
| 18 | Jimmie Foxx | 20 | 1751 |
| 19 | Honus Wagner | 21 | 1736 |
| 20 | Jim O'rourke | 23 | 1729 |
| 21 | Jesse Burkett | 16 | 1720 |
| 22 | Willie Keeler | 19 | 1719 |
| 23 | Barry Bonds | 16 | 1713 |
| 24 | Billy Hamilton | 14 | 1690 |
| 25 | Bid McPhee | 18 | 1678 |
| 26 | Mickey Mantle | 18 | 1677 |
| 27 | Dave Winfield | 22 | 1669 |
| 28 | Joe Morgan | 22 | 1650 |
| 29 | Cal Ripken | 21 | 1647 |
| 30 | Jimmy Ryan | 18 | 1642 |
| 31 | George Vanhaltren | 17 | 1639 |
| 32 | Robin Yount | 20 | 1632 |
| 33 | Paul Waner | 20 | 1627 |
| 34 | Eddie Murray | 21 | 1627 |
| 35 | Al Kaline | 22 | 1622 |
| 36 | Roger Connor | 18 | 1620 |
| 37 | Fred Clarke | 21 | 1619 |
| 38 | Lou Brock | 19 | 1610 |
| 39 | Jake Beckley | 20 | 1600 |
| 40 | Ed Delahanty | 16 | 1599 |
| 41 | Bill Dahlen | 21 | 1589 |
| 42 | George Brett | 21 | 1583 |
| 43 | Rogers Hornsby | 23 | 1579 |
| 44 | Tim Raines | 22 | 1562 |
| 45 | Hugh Duffy | 17 | 1552 |
| 46 | Reggie Jackson | 21 | 1551 |
| 47 | Max Carey | 20 | 1545 |
| 48 | George Davis | 20 | 1539 |
| 49 | Frankie Frisch | 19 | 1532 |
| 50 | Dan Brouthers | 19 | 1523 |